NSC 4123
2,6-Dichloro-4-nitrophenol
CAS: 618-80-4
Molecular Formula: C6H3Cl2NO3
NSC 4123 - Names and Identifiers
| Name | 2,6-Dichloro-4-nitrophenol |
| Synonyms | NSC 4123 AI3-03649 2,6-Dichloro-4-nitro 6-dichloro-4-nitrophenol 4-Nitro-2,6-dichlorophenol 2,6-DICHLORO-4-NITROPHENOL 2,6-Dichloro-4-nitrophenol 2,6-dichloro-4-nitro-pheno 2,6-dichloro-4-nitrophenolate Phenol, 2,6-dichloro-4-nitro- |
| CAS | 618-80-4 |
| EINECS | 210-563-6 |
| InChI | InChI=1/C6H3Cl2NO3/c7-4-1-3(9(11)12)2-5(8)6(4)10/h1-2,10H/p-1 |
NSC 4123 - Physico-chemical Properties
| Molecular Formula | C6H3Cl2NO3 |
| Molar Mass | 208 |
| Density | 1.8220 |
| Melting Point | 123-126°C (dec.) |
| Boling Point | 285.2±40.0 °C(Predicted) |
| Flash Point | 126.3°C |
| Solubility | soluble in Methanol |
| Vapor Presure | 0.00165mmHg at 25°C |
| Appearance | powder to crystal |
| Color | Light orange to Yellow to Green |
| BRN | 1245045 |
| pKa | 3.81±0.44(Predicted) |
| Refractive Index | 1.5650 (estimate) |
| Physical and Chemical Properties | Natural color is light brown crystal, m. P. 127 ℃, soluble in ether, chloroform and hot ethanol, insoluble in water and benzene. |
| Use | Used as an intermediate in organic synthesis |
NSC 4123 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | UN 2811 6.1/PG 1 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 29089990 |
| Hazard Class | 4.1 |
| Packing Group | III |
NSC 4123 - Nature
Open Data Verified Data
light brown crystals. Melting point 125 °c (decomposition). Soluble in ether, chloroform and hot ethanol, insoluble in water and benzene.
Last Update：2024-01-02 23:10:35
NSC 4123 - Preparation Method
Open Data Verified Data
p-nitrophenol is dissolved in ethanol, then Potassium chlorate aqueous solution is continuously added in hydrochloric acid solution, after crystallization, the crude product is obtained by filtration and washing with water, and recrystallized with chloroform or ethanol, then with petroleum ether extraction, cooling, crystallization and to obtain fine.
Last Update：2022-01-01 10:50:23
NSC 4123 - Application
Open Data Verified Data
intermediates in organic synthesis.
Last Update：2025-08-19 16:24:40
NSC 4123 - Safety
Open Data Verified Data
- see 2,6-= chloro-4-nitroaniline (C290) for toxicity and protection.
- shall be packed in iron drum and stored in a dry and well-ventilated place. The hazardous materials shall be stored and transported according to the regulations.
Last Update：2025-06-10 22:55:16
NSC 4123 - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Use | 2, 6-dichloro-4-nitrophenol is an organic synthesis intermediate, which is used in the synthesis of fluorolluron on pesticides Intermediate 2, 6-dichloro-4-aminophenol. Used as an intermediate in organic synthesis |
| Production method | The preparation method is to chlorinate p-nitrophenol with potassium chlorate and hydrochloric acid to obtain 2, 6-dichloro-4-nitrophenol. Dissolve p-nitrophenol in ethanol, then pour it into concentrated hydrochloric acid, cool to below 5 ℃, and add potassium chlorate aqueous solution under constant stirring, control the temperature below 10 ℃, filter out and wash into crude products. Recrystallize once with ethanol, then heat and dissolve with a mixed solvent of chloroform and ethanol, decolorize and filter, add petroleum ether to the filtrate, and cool to precipitate and crystallize to obtain the finished product. p-nitrophenol is dissolved in ethanol, and then potassium chlorate aqueous solution is continuously added in hydrochloric acid solution. After crystallization and precipitation, the crude product is obtained by filtration and washing with water, recrystallized with chloroform or ethanol, and then extracted with petroleum ether, cooled and crystallized to obtain fine products. |
Last Update：2024-04-09 19:05:09
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